Postdoctoral position in Bioinformatics

Title Postdoctoral position in Bioinformatics
Location PENG group, Prinses Maxima Center.
Job Information

Postdoctoral position in Bioinformatics – PENG group, Prinses Maxima Center.

We are looking for a highly motivated postdoc to join the Peng lab at the Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

We are a stem-cell biology lab with focus on childhood liver cancer and regenerative medicine based on organoid technology. We are currently looking for a postdoc to analyze genomics and RNA-seq data to elucidate the molecular mechanism of childhood liver cancer and liver regeneration.

We employ cutting-edge genomic approaches, in vitro system (e.g., gene-editing, advanced imaging, high throughput drug screening in organoids) and in vivo model (e.g., transplantation of tumor cells in mouse model) to uncover the key signaling events underlying the development of liver tumor and the role of tumor microenvironment. A unique strength of the lab is we were the first to establish primary hepatocyte 3D culture that are highly efficient in repopulating the injured liver of mice (Peng et al., Cell, 2018). Our overall goals are to better understand liver tumor pathobiology and to develop novel therapeutics (e.g., antibodies) using primary tumor samples and organoid models.

Your qualifications and tasks

  • Ph.D. in Bioinformatics, Computational Biology or related disciplines (and a strong passion for data analysis)
  • Excellent bioinformatics and programming skills (Python, R)
  • Experience in the analysis of NGS data (WGS/WES, RNA-seq, ChIP-seq, ATAC-seq,

    methylome, spatial transcriptomics)

  • Apply available and develop new bioinformatic tools and pipelines for the analysis of NGS

    datasets

  • Explore public database, manage and store large NGS datasets
  • Familiar with NGS sample preparation procedures

    Who we are

    The Princess Máxima Center for Pediatric Oncology is a new nationwide research hospital concentrating healthcare, research and education with regard to cancer in children and is located in the Utrecht Science Park. The institute aims to give the best treatment to children with cancer with the highest cure rate and the least side effects of (often complex) anti-cancer treatment. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

    We offer

    A full-time position (based on 36 hours a week) in a very stimulating and cross-disciplinary research environment. You will also have the opportunity to collaborate actively with other bioinformatic groups at the Maxima and the Utrecht Bioinformatics Center (UBC) and the opportunity to do web-lab experiments, depending on one’s interests.

    The Princess Máxima Center operates according to the collective labour agreement ‘CAO ziekenhuizen’. Your gross monthly salary will be based on your background and experience with a maximum of EUR 4.303 (scale 60), supplemented with 8.33% holiday allowance and end-of-year bonus.

    How to apply

  • CV (1- 2 pages)
  • A short motivation letter describing your background and interests
  • Contact info of 2 – 3 referees, or reference letters if available.

    For more information please contact Dr. Weng Chuan Peng (w.c.peng prinsesmaximacentrum.nl)

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