{"id":9556,"date":"2026-07-22T11:38:55","date_gmt":"2026-07-22T09:38:55","guid":{"rendered":"https:\/\/ubc.uu.nl\/?p=9556"},"modified":"2026-07-22T11:44:38","modified_gmt":"2026-07-22T09:44:38","slug":"new-genetic-clues-bring-targeted-als-therapies-closer","status":"publish","type":"post","link":"https:\/\/ubc.uu.nl\/new-genetic-clues-bring-targeted-als-therapies-closer\/","title":{"rendered":"New genetic clues bring targeted ALS therapies closer"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9556\" class=\"elementor elementor-9556\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-10012973 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"10012973\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-701ae7b3\" data-id=\"701ae7b3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-397a2030 elementor-widget elementor-widget-text-editor\" data-id=\"397a2030\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n    <div style=\"display:flex; align-items:flex-start; gap:30px;\">\n\n        <div style=\"flex:1; padding:0; margin:0;\">\n\n            Researchers at the ALS Center UMC Utrecht have identified new genetic variants linked to ALS, increasing the proportion of patients with a known genetic cause from 20 to 25%. These findings provide important insights into the disease and lay the groundwork for developing targeted gene therapies for ALS. The study was published in <i>Nature Genetics<\/i> by first author Paul Hop  under the co-supervision of Professor Jan Veldink and Kevin Kenna. Read the <a href=\"https:\/\/mailings.uu.nl\/i\/JIEpiwlGl-Kyw7k5S-iX-pZAwVHNs_l1\">news story<\/a> at the UMC Utrecht website (available in Dutch only) or <a href=\"https:\/\/mailings.uu.nl\/i\/pFfCLaYB7P_lJCy1ECF5sxfCCMb35Z9j\">this article<\/a> in English.\n\n            <p style=\"margin-top:15px; margin-bottom:0;\">\n                <a href=\"https:\/\/mailings.uu.nl\/i\/bX7HCenffXqNrS5SpQsD60pVLFfpKb-y\"\n                   style=\"font-weight:bold;\">\n                    Read more\n                <\/a>\n            <\/p>\n\n        <\/div>\n\n\n        <div style=\"width:250px; margin:0; padding:0;\">\n\n            <img decoding=\"async\" \n                src=\"https:\/\/mailings.uu.nl\/c\/hOmk1hd6LhhRDJWQaqlcjQ\/media\/UBC-ALS-Centrum_1.jpg\"\n                alt=\"New genetic clues bring targeted ALS therapies closer\"\n                style=\"\n                    width:250px;\n                    max-width:100%;\n                    height:auto;\n                    display:block;\n                    margin:0;\n                \"\n            \/>\n\n        <\/div>\n\n    <\/div>\n    \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Researchers at the ALS Center UMC Utrecht have identified new genetic variants linked to ALS, increasing the proportion of patients with a known genetic cause from 20 to 25%. These findings provide important insights into the disease and lay the groundwork for developing targeted gene therapies for ALS. The study was published in Nature Genetics [&hellip;]<\/p>\n","protected":false},"author":94,"featured_media":9526,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_angie_page":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"page_builder":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[408,397],"tags":[],"class_list":["post-9556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news_freestyle","category-research"],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/ubc.uu.nl\/wp-content\/uploads\/2026\/07\/UBC-ALS-Centrum_1.jpg","_links":{"self":[{"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/posts\/9556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/users\/94"}],"replies":[{"embeddable":true,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/comments?post=9556"}],"version-history":[{"count":4,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/posts\/9556\/revisions"}],"predecessor-version":[{"id":9604,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/posts\/9556\/revisions\/9604"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/media\/9526"}],"wp:attachment":[{"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/media?parent=9556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/categories?post=9556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ubc.uu.nl\/wp-json\/wp\/v2\/tags?post=9556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}