The focus of our research is on the relationship of transcription factors and their target-genes and how this can generate diverse cellular states and therefore contribute to cancer cell heterogeneity. Particularly, our research lines aim to shed light on (1) the reprogramming of chromatin-related factors in relation to lineage plasticity; (2) transcription factor structure-function in locus-specific gene regulation and genome biology; and (3) cancer cell heterogeneity on single-cell level. To explore these the lab integrates various structural, omics, and computational approaches.