Fungi are impacting human societies through the production of bioactive molecules known as secondary metabolites (SMs), such as the first broad spectrum antibiotic penicillin. The aim of the Fungal Natural Product group is to identify, characterize and apply fungal secondary metabolites in order to provide solutions to medicine, industry and agriculture. For this, we are exploiting the whole fungal kingdom and study the evolution of SM biosynthesis in fungi, employing a multidisciplinary approach that combines bioinformatics, genomics, synthetic biology, bioassays and chemistry. Our focus applications are diverse, including development of genome mining tools, discovery of new antimicrobials and development of fungal dyes.