Our research is focused on uncovering the mechanisms regulating the pool of stem cells in roots. Towards this goal, we develop computational models to describe the gene regulatory and protein-complex dynamic networks underlying cell fate, and study them in the context of the root apex using multicellular models. This integrative approach allows us to explore the coordinated action of different pieces of the root development puzzle with the aim of understanding how the size, patterning and regenerative capabilities of root is regulated in different species.