Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.
To understand regulatory systems, it would be useful to uniformly determine how different components contribute to the expression of all other genes. We therefore monitored mRNA expression genome-wide, for individual deletions of one-quarter of yeast genes, focusing on (putative) regulators. The resulting genetic perturbation signatures reflect many different properties. These include the architecture of protein […]
Systematic integrative genomics, transcriptomics and ultra-deep proteomics analysis reveals novel insight in disease biology
Experts in proteomics from Utrecht University and next-generation DNA sequencing from the Hubrecht Institute/UMC Utrecht collaborated in a study to systematically determine the consequences of genetic variation on the transcriptome and proteome. The researchers applied ultra-deep quantitative proteomics, whole genome sequencing and RNA-seq to liver tissues from different inbred rat strains. One of these inbred […]
Bioinformatics the foundation of life sciences
The Utrecht Bioinformatics Cluster brings together our strong bioinformatics community by organising and promoting strong interactions between the different groups. Together we are the foundation on which the life science research is build enabling better, more efficient and excellent in depth research.