The Princess Maxima Center for Pediatric Oncology is a new research hospital concentrating healthcare, research and education with regard to cancer in children in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and significantly reduce unwanted side effects. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
The candidate will be part of the diagnostic bioinformatics group at the Princess Maxima Center. This group is responsible for performing the data analysis for all clinical NGS and array experiments. We have extensive experience with implementing novel technologies in a diagnostic setting and coordinating bioinformatics infrastructures such as High-Performance Computing, workflow management systems and data sharing and collaboration facilities.
As part of the diagnostics conducted at the Princess Maxima Center, exome sequencing, RNAseq and methylation array data is generated for all individual patients. The NGS genomics platform is part of a shared diagnostics and research infrastructure currently being developed at the Princess MÃ¡xima Center together with bioinformaticians within the Kemmeren group. The candidate will be responsible for performing analysis with the data analysis pipelines generated in house, as well as maintaining these pipelines.
Tasks and responsibilities
The candidate will play a significant role in the data analysis as well as development, implementation and integration of the NGS genomics platform at the Princess MÃ¡xima Center. The candidate will work in close collaboration with bioinformaticians and laboratory specialists in both the Kemmeren group as well as diagnostics
Specific tasks include:
- Analysis of exome and RNAseq NGS data, as well as methylation arrays,
- Development and implementation NGS genomics platform using Molgenis, WDL, Cromwell, REST and large-scale computational infrastructures.
- Coordination of clinical NGS data analysis.
- Setting up and supporting bioinformatic analysis pipelines and questions.
Skills and education
We expect a highly motivated candidate with a bachelor or master in bioinformatics or similar experience in bioinformatics or data science. Excellent technical and programming skills are required, preferably in R, perl, python, java and/or C. Knowledge about next-generation sequencing, genetics, statistics and large-scale computational infrastructures are also preferred. The candidate should also have good communication skills, be flexible, versatile and a good team player.
Working at the Princess Maxima Centre
We offer a temporary, full time position (36 hours a week for three years) as a bioinformatician at the Princess MÃ¡xima Center. You will be working in a very stimulating and cross-disciplinary research environment, combining cutting-edge research with state-of-the-art bioinformatics. Gross monthly salary will depend on experience and background with a maximum of 3.840 euro per month (scale 50-55), increased with 8% holiday allowance and 8.33% end-of-year bonus. The Princess Maxima Center is covered by the collective labor agreement CAO ziekenhuizen.
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