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The Group
De Laat Lab
Biomedical Genomics
Hubrecht Institute
Address / Contact
Uppsalalaan 8
3584 CT
Utrecht
+31 (0)30 212 18 00
-
Hubrecht Building
Research
Biomedical genomics
The architecture of DNA in the interior of the living cell nucleus is an emerging key contributor to genomic function. Aim of our research is to understand how genome structure influences genome function. We use and develop novel genomics approaches such as 4C technology to identify long-range DNA interactions, study gene regulation within and between mammalian chromosomes and uncover the proteins that dictate the shape of our genome. Besides transcription we study the impact of nuclear architecture on genomic rearrangements. Furthermore, we develop novel strategies to identify and map chromosomal aberrations.