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Van Boxtel LabMutational landscapes in stem cells and cancer
We combine genomics, in-depth mutational analyses and stem cell culture technology to identify and study the processes that cause cancer.
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The Group
Van Boxtel Lab
Mutational landscapes in stem cells and cancer
Princess Máxima Center for Pediatric Oncology
Address / Contact
Uppsalalaan 8
3584 CT
Utrecht
Hubrecht
088 972 55 05
E3.24
Research

Gradual accumulation of somatic mutations in adult stem cells is believed to contribute to cancer development. By combining genome-wide sequencing and stem cell culture technologies, we aim to characterize tissue-specific mutation accumulation in adult stem cells during life and related to disease development. The ultimate goal of these studies is to obtain novel fundamental insight into the processes that shape mutational landscapes in stem cells, a critical step towards understanding cancer aetiology and the development of future therapeutic efforts aimed at prevention.